How should I take Mifepristone and Misoprostol?


These instructions are for a pregnancy that is up to 12 weeks (84 days), counting from the first day of the last menstrual period (LMP). The evidence suggests that mifepristone plus misoprostol are very safe and effective to 12 weeks. After 12 weeks, there is a higher chance of a complication and the medicines are used differently.

1st - Mifepristone should be swallowed with a glass of water.

2nd - 24 hours later the woman should put 4 pills of misoprostol buccally (between the gum and the cheek).

She should put two tablets into her mouth, between her gum and cheek, on the left side and two more tablets between the gum and cheek, on the right side.

All four pills should be left in the mouth for approximately 30 minutes to dissolve. Women shouldn’t eat or drink anything while the pills are dissolving. Anything left in the mouth after 30 minutes should be swallowed.  Before and after using the misoprostol she can eat and drink normally, but should not use drugs or alcohol; she needs to pay attention to her body.